2022
- TKI Treatment Sequencing in Advanced Gastrointestinal Stromal Tumors. Download PDF PMID: 36607590
- Patient-reported outcomes in individuals with advanced gastrointestinal stromal tumor treated with ripretinib in the fourth-line setting: analysis from the phase 3 INVICTUS trial Download PDF PMID: 36514034
- Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial. Download PDF PMID: 35947817
- Ten-Year Survivorship in Patients with Metastatic Gastrointestinal Stromal Tumors. Download PDF PMID: 35829795
- A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor, Download PDF PMID 35524239
- Neoadjuvant tyrosine kinase inhibitor therapy for patients with gastrointestinal stromal tumor: A propensity-matched analysis. Download PDF PMID 35382931
- New treatment strategies for advanced-stage gastrointestinal stromal tumours. Download PDF PMID 35217782
- Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers. Download PDF PMID 35091442
- Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response. Download PDF PMID 34426440
2021
- Ripretinib intrapatient dose escalation after disease progression provides clinically meaningful outcomes in advanced gastrointestinal stromal tumour. Download PDF PMID 34391056
- Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor: A Randomized, Open-Label Phase III Study. Download PDF PMID 34343033
- Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity. Download PDF PMID 34326133
- Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor. Download PDF PMID 34322383
- Hepatic metastases in gastrointestinal stromal tumors: oncologic outcomes with curative-intent hepatectomy, resection of treatment-resistant disease, and tyrosine kinase inhibitor therapy alone. Download PDF PMID 34924291
- Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study. Download PDF PMID 34503977
- Clinical Benefit of Ripretinib Dose Escalation After Disease Progression in Advanced Gastrointestinal Stromal Tumor: An Analysis of the INVICTUS Study. Download PDF PMID 34313371
- Imatinib-resistant gastrointestinal stromal tumors in the era of second- and third-line tyrosine kinase inhibitors: Does surgical resection have a role? Download PDF PMID 34090672
- ASO Author Reflections: The Disease-Free Interval is Associated with Oncologic Outcomes for Patients with Recurrent Gastrointestinal Stromal Tumor. Download PDF PMID 33987756
- Inhibition of KIT Tyrosine Kinase Activity: Two Decades After the First Approval. Download PDF PMID 33797935
- Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinical trial and real-world data. Download PDF PMID 33740926
- Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis. Download PDF PMID 33603171
- Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial. Download PDF PMID 33465704
- Avapritinib in Patients With Advanced Gastrointestinal Stromal Tumors Following at Least 3 Prior Lines of Therapy. Download PDF PMID: 33453089
2020
- Identification of Wee1 as target in combination with avapritinib for Gastrointestinal Stromal Tumor treatment. Download PDF PMID: 33320833
- Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib. Download PDF PMID: 32804590
- Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain. Download PDF PMID: 32972961
- Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial. Download PDF PMID: 32511981
- Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial. Download PDF PMID: 32615108
- Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study. Download PDF PMID: 31792037
2019
- Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib. Download PDF PMID: 31755321
- KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors - TORC1/2 Inhibition as Salvage Strategy. Download PDF PMID: 31308077
- Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Registry. Download PDF PMID: 30984366
- Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs). Download PDF PMID: 30867899
- Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Download PDF PMID: 31085175
- Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours. Download PDF PMID: 30792533
- LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma. Download PDF PMID: 30242244
2018
- Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases. Download PDF PMID: 2996412
- Translational insights into gastrointestinal stromal tumor and current clinical advances. Download PDF PMID: 30101284
- Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene. Download PDF PMID: 29510530
2017
- A precision therapy against cancers driven by KIT/PDGFRA mutations. Download PDF PMID: 29093181
- Defining the Impact of Adjuvant Therapy in Molecularly Defined Subsets of Gastrointestinal Stromal Tumor : From Lumping to Splitting. Download PDF PMID: 28334361
- Gastrointestinal stromal tumours of the oesophagus: a clinicopathological and molecular analysis of 27 cases. Download PDF
- Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance. Download PDF PMID: 28724664
- Using molecular diagnostic testing to personalize the treatment of patients with gastrointestinal stromal tumors. Download PDF PMID: 28317407
- MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation. Download PDF PMID: 28270683
- Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033. PMID: 28196207
- PDGFRA Antibody for Soft Tissue Sarcoma. Download PDF PMID: 28187274
2016
- FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. Download PDF PMID: 27974047
- Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib. PMID: 27167336
- Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour. Download PDF PMID: 27156227
- Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial. Download PDF PMID: 26772734
2015
- S0502: A SWOG Phase III Randomized Study of Imatinib, With or Without Bevacizumab, in Patients With Untreated Metastatic or Unresectable Gastrointestinal Stromal Tumors. Download PDF PMID: 26576593
- Utility of BRAF V600E mutation-specific immunohistochemistry in detecting BRAF V600E-mutated gastrointestinal stromal tumors. Download PDF PMID: 26486743
- SDHC methylation in gastrointestinal stromal tumors (GIST): a case report. Download PDF PMID: 26415883
- Genotyping and immunohistochemistry of gastrointestinal stromal tumors: An update. PMID: 25766843
- Template for Reporting Results of Biomarker Testing of Specimens From Patients With Gastrointestinal Stromal Tumors. Download PDF PMID: 25729899
- Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition. Download PDF PMID: 25695690
- Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance. Download PDF PMID: 25432174
- Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways. Download PDF PMID: 25165019
2014
- Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST). Download PDF PMID: 25239601
- Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients. Download PDF PMID: 25239608
- Combination therapy for KIT-mutant mast cells: Targeting constitutive NFAT and KIT activity. Download PDF PMID: 25253785
- Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract. Download PDF PMID: 24842760
- Regorafenib for treatment of advanced gastrointestinal stromal tumors. Download PDF PMID: 24405315
- KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation. PMID: 24687822
- Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. PMID: 24638003
- Novel Mutations in Neuroendocrine Carcinoma of the Breast: Possible Therapeutic Targets. Download PDF PMID: 24569783
- Gastrointestinal stromal tumors: what do we know now? Download PDF PMID: 24384849
2013
- Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin. Download PDF PMID: 23775962
- Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia. Download PDF PMID: 23705826
- Gastrointestinal stromal tumour.Download PDF PMID: 23623056
- Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Download PDF PMID: 23497317
- Combining Highly Multiplexed PCR with Semiconductor-Based Sequencing for Rapid Cancer Genotyping. PMID: 23274167
- BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance. Download PDF
- Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.Download PDF PMID: 23313954
2012
- Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours. PMID: 22777070
- Regorafenib Induces Rapid and Reversible Changes in Plasma Nitric Oxide and Endothelin-1. Download PDF PMID: 22785409
- Crenolanib Inhibits the Drug-Resistant PDGFRA D842V Mutation Associated with Imatinib-resistant Gastrointestinal Stromal Tumors. Download PDF PMID: 22745105
- Mucinous breast carcinomas lack PIK3CA and AKT1 mutations. Download PDF PMID: 22705004
- Sorafenib Inhibits Many Kinase Mutations Associated with Drug-Resistant Gastrointestinal Stromal Tumors. Download PDF PMID: 22665524
- Multiplex high-throughput gene mutation analysis in acute myeloid leukemia. Download PDF PMID: 22658276
- Efficacy and Safety of Regorafenib in Patients With Metastatic and/or Unresectable GI Stromal Tumor After Failure of Imatinib and Sunitinib: A Multicenter Phase II Trial. Download PDF PMID: 22614970
- Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132. Download PDF PMID: 22203182 Erratum to "Phase II..."
- Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study. Download PDF PMID: 22804613
2011
- Differential expression of neural markers in KIT and PDGFRA wild-type gastrointestinal stromal tumors. Download PDF PMID: 22175887
- Gastrointestinal stromal tumours: origin and molecular oncology. Download PDF PMID: 22089421
- A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis): case series of 28 patients. Download PDF PMID: 21994214
- Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs. Download PDF PMID: 21953054
- Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry. Download PDF PMID: 21726664
- "Pediatric-type" Gastrointestinal Stromal Tumors in Adults: Distinctive Histology Predicts Genotype and Clinical Behavior. Download PDF PMID: 21358303